PT  - JOURNAL ARTICLE
AU  - Kinuko Kono
AU  - Yuichi Inoue
AU  - Keiko Nakayama
AU  - Miyuki Shakudo
AU  - Michiharu Morino
AU  - Kenji Ohata
AU  - Kenichi Wakasa
AU  - Ryusaku Yamada
TI  - The Role of Diffusion-weighted Imaging in Patients with Brain Tumors
DP  - 2001 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1081--1088
VI  - 22
IP  - 6
4099  - http://www.ajnr.org/content/22/6/1081.short
4100  - http://www.ajnr.org/content/22/6/1081.full
SO  - Am. J. Neuroradiol.2001 Jun 01; 22
AB  - BACKGROUND AND PURPOSE: Diffusion-weighted images (DWIs) have been used to study various diseases, particularly since echo-planar techniques shorten examination time. Our hypothesis was that DWIs and tumor apparent diffusion coefficients (ADCs) could provide additional useful information in the diagnosis of patients with brain tumors.METHODS: Using a 1.5-T MR unit, we examined 56 patients with histologically verified or clinically diagnosed brain tumors (17 gliomas, 21 metastatic tumors, and 18 meningiomas). We determined ADC values and signal intensities on DWIs both in the solid portion of the tumor and in the peritumoral, hyperintense areas on T2-weighted images. We also evaluated the correlation between ADC values and tumor cellularity in both gliomas and meningiomas.RESULTS: The ADCs of low-grade (grade II) astrocytomas were significantly higher (P = .0004) than those of other tumors. Among astrocytic tumors, ADCs were higher in grade II astrocytomas (1.14 ± 0.18) than in glioblastomas (0.82 ± 0.13). ADCs and DWIs were not useful in determining the presence of peritumoral neoplastic cell infiltration. The ADC values correlated with tumor cellularity for both astrocytic tumors (r = −.77) and meningiomas (r = −.67).CONCLUSION: The ADC may predict the degree of malignancy of astrocytic tumors, although there is some overlap between ADCs of grade II astrocytomas and glioblastomas.