RT Journal Article
SR Electronic
T1 Central Processing of Rectal Pain: A Functional MR Imaging Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1920
OP 1924
VO 20
IS 10
A1 Monica V. Baciu
A1 Bruno L. Bonaz
A1 Emmanuel Papillon
A1 Richard A. Bost
A1 Jean-François Le Bas
A1 Jacques Fournet
A1 Christoph M. Segebarth
YR 1999
UL http://www.ajnr.org/content/20/10/1920.abstract
AB BACKGROUND AND PURPOSE: Although the central processing of somatic pain has been dealt with in numerous brain imaging studies, the neural correlates of visceral pain have received much more limited attention. Our goal was to assess the feasibility of detecting brain activation patterns induced by rectal pain by means of functional MR imaging. We hypothesized that the cerebral processing of rectal pain would exhibit strong similarities with the central processing of somatic pain.METHODS: Functional MR imaging data were obtained from eight healthy subjects. A block paradigm was applied. Rectal pain was induced by inflating a latex balloon catheter that had been inserted into the rectum. Functional responses were established by means of cross-correlation analysis.RESULTS: Activation was detected within the anterior cingulate gyrus, the prefrontal cortex, the insular cortex, the sensory-motor cortex, the inferior parietal lobule, the posterior cingulate gyrus, and the visual cortex.CONCLUSION: Functional MR imaging of visceral pain is feasible in healthy subjects. The activation patterns observed in this study support the hypothesis that the cerebral processing of visceral pain involves multiple components, similar to the central processing of somatic pain. Our results constitute a first step toward the identification of possible aberrations in the activation patterns of patients suffering from visceral hypersensitivity.