RT Journal Article
SR Electronic
T1 Decreased Diffusion in Central Pontine Myelinolysis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1476
OP 1479
VO 22
IS 8
A1 Cramer, Steven C.
A1 Stegbauer, Keith C.
A1 Schneider, Alex
A1 Mukai, John
A1 Maravilla, Kenneth R.
YR 2001
UL http://www.ajnr.org/content/22/8/1476.abstract
AB Summary: Two patients with central pontine myelinolysis (CPM) were studied with diffusion-weighted MR imaging 1 week after onset of tetraplegia. In both patients, affected white matter showed hyperintensity on diffusion-weighted images associated with a decrease in apparent diffusion coefficient (ADC) values. In one patient studied serially, ADC values normalized by 3 weeks after tetraplegia. Early in the clinical course, diagnosis of CPM can sometimes be difficult. Hyperintensity on diffusion-weighted images may therefore have diagnostic utility. Decreased lesional ADC values support the notion that CPM is a consequence of relative intracellular hypotonicity.