PT  - JOURNAL ARTICLE
AU  - Salzman, Karen L.
AU  - Osborn, Anne G.
AU  - House, Paul
AU  - Jinkins, J. Randy
AU  - Ditchfield, Adam
AU  - Cooper, James A.
AU  - Weller, Roy O.
TI  - Giant Tumefactive Perivascular Spaces
DP  - 2005 Feb 01
TA  - American Journal of Neuroradiology
PG  - 298--305
VI  - 26
IP  - 2
4099  - http://www.ajnr.org/content/26/2/298.short
4100  - http://www.ajnr.org/content/26/2/298.full
SO  - Am. J. Neuroradiol.2005 Feb 01; 26
AB  - BACKGROUND AND PURPOSE: The brain perivascular spaces (PVSs) are pial-lined, interstitial fluid-filled structures that accompany penetrating arteries. When enlarged, they may cause mass effect and can be mistaken for more ominous pathologic processes. The purpose of this study was to delineate the broad clinical and imaging spectrum of this unusual condition.METHODS: Thirty-seven cases of giant PVSs were identified from 1988 to 2004 and were retrospectively reviewed. Clinical data collected included patient demographics, presenting symptoms, and follow-up. Histopathologic data were reviewed when available. Images were evaluated for size and location of the giant PVSs, associated mass effect, hydrocephalus, adjacent white matter changes, and contrast enhancement.RESULTS: There were 24 men and 13 women with an age range of 6–86 years, (mean 46 years). The most common presenting feature was headache (15 patients). Thirty-two cases had multilocular clusters of variably sized cysts. Five lesions were unilocular. All lesions had signal intensity comparable to CSF and did not enhance. The most common location for the giant PVSs was the mesencephalothalamic region (21/36). Fourteen were located in the cerebral white matter; two were in the dentate nuclei. Nine giant mesencephalothalamic PVSs had associated hydrocephalus, which required surgical intervention.CONCLUSION: Giant tumefactive PVSs most often appear as clusters of variably sized cysts that are isointense relative to CSF and do not enhance. They are most common in the mesencephalothalamic region and may cause hydrocephalus. Although they may have striking mass effect, giant PVSs should not be mistaken for neoplasm or other diseases.