PT  - JOURNAL ARTICLE
AU  - Maria A. Rocca
AU  - Domenico M. Mezzapesa
AU  - Angelo Ghezzi
AU  - Andrea Falini
AU  - Vittorio Martinelli
AU  - Giuseppe Scotti
AU  - Giancarlo Comi
AU  - Massimo Filippi
TI  - A Widespread Pattern of Cortical Activations in Patients at Presentation with Clinically Isolated Symptoms Is Associated with Evolution to Definite Multiple Sclerosis
DP  - 2005 May 01
TA  - American Journal of Neuroradiology
PG  - 1136--1139
VI  - 26
IP  - 5
4099  - http://www.ajnr.org/content/26/5/1136.short
4100  - http://www.ajnr.org/content/26/5/1136.full
SO  - Am. J. Neuroradiol.2005 May 01; 26
AB  - BACKGROUND AND PURPOSE: Movement-associated cortical changes have been detected at the earlier clinical stage multiple sclerosis. Our purpose was to assess whether different patterns of cortical recruitment are associated with the short-term evolution of definite multiple sclerosis (MS).METHODS: We followed for 1 year a group of patients with clinically isolated syndromes (CISs) suggestive of MS and compared the baseline movement-associated patterns of cortical activations between those patients with and those without evolution to definite MS.RESULTS: Those patients in whom MS did not evolve had more significant activations of several areas part of the “classic” motor network; those who went on to develop MS had more significant activations of several regions in the frontal, parietal, temporal, and occipital lobes.CONCLUSION: In CIS patients, the extent of early cortical reorganization following tissue injury might be a factor associated with a different disease evolution.