RT Journal Article
SR Electronic
T1 A Widespread Pattern of Cortical Activations in Patients at Presentation with Clinically Isolated Symptoms Is Associated with Evolution to Definite Multiple Sclerosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1136
OP 1139
VO 26
IS 5
A1 Maria A. Rocca
A1 Domenico M. Mezzapesa
A1 Angelo Ghezzi
A1 Andrea Falini
A1 Vittorio Martinelli
A1 Giuseppe Scotti
A1 Giancarlo Comi
A1 Massimo Filippi
YR 2005
UL http://www.ajnr.org/content/26/5/1136.abstract
AB BACKGROUND AND PURPOSE: Movement-associated cortical changes have been detected at the earlier clinical stage multiple sclerosis. Our purpose was to assess whether different patterns of cortical recruitment are associated with the short-term evolution of definite multiple sclerosis (MS).METHODS: We followed for 1 year a group of patients with clinically isolated syndromes (CISs) suggestive of MS and compared the baseline movement-associated patterns of cortical activations between those patients with and those without evolution to definite MS.RESULTS: Those patients in whom MS did not evolve had more significant activations of several areas part of the “classic” motor network; those who went on to develop MS had more significant activations of several regions in the frontal, parietal, temporal, and occipital lobes.CONCLUSION: In CIS patients, the extent of early cortical reorganization following tissue injury might be a factor associated with a different disease evolution.