RT Journal Article SR Electronic T1 Serial MR Imaging Findings of Acute Hemorrhagic Leukoencephalitis: A Case Report JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1996 OP 1999 VO 26 IS 8 A1 Lee, Ho Yun A1 Chang, Kee-Hyun A1 Kim, Ji Hoon A1 Na, Dong Gyu A1 Kwon, Bae Ju A1 Lee, Kwang-Woo A1 Park, Sung Hye YR 2005 UL http://www.ajnr.org/content/26/8/1996.abstract AB Summary: We report a patient with acute hemorrhagic leukoencephalitis with a focus on serial MR imaging findings. Initial MR imaging of a 42-year-old woman revealed a 2.5-cm focal nonhemorrhagic lesion in the left thalamus and internal capsule. Twenty-four days later, fever and altered consciousness developed, and MR imaging showed huge masslike lesions in both frontal lobes, mainly involving the white matter and the genu of the corpus callosum, with massive edematous swelling that contained multifocal small hemorrhages. Most lesions showed high apparent diffusion coefficient value with peripheral small areas of low apparent diffusion coefficient. On follow-up MR imaging obtained 49 days after initial MR imaging, the lesions progressed with increase in extent and development of rim-enhancing necrosis, despite steroid therapy. Following stereotactic biopsy and subsequent high-dose steroid treatment, the patient recovered with some neurologic sequelae. MR imaging obtained at 72 and 126 days revealed residual necrosis and cerebromalacia in the both frontal lobes.