PT  - JOURNAL ARTICLE
AU  - de Leon, M J
AU  - Ferris, S H
AU  - George, A E
AU  - Christman, D R
AU  - Fowler, J S
AU  - Gentes, C
AU  - Reisberg, B
AU  - Gee, B
AU  - Emmerich, M
AU  - Yonekura, Y
AU  - Brodie, J
AU  - Kricheff, I I
AU  - Wolf, A P
TI  - Positron emission tomographic studies of aging and Alzheimer disease.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 568--571
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/568.short
4100  - http://www.ajnr.org/content/4/3/568.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.