PT  - JOURNAL ARTICLE
AU  - E Holtz
AU  - A A Michelet
AU  - T Jacobsen
TI  - Absorption after subarachnoid and subdural administration of iohexol, 51Cr-EDTA, and 125I-albumin to rabbits.
DP  - 1983 May 01
TA  - American Journal of Neuroradiology
PG  - 338--341
VI  - 4
IP  - 3
4099  - http://www.ajnr.org/content/4/3/338.short
4100  - http://www.ajnr.org/content/4/3/338.full
SO  - Am. J. Neuroradiol.1983 May 01; 4
AB  - The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a subarachnoid injection of the two substances, where a slow absorption to lower blood concentrations was observed. No significant differences in absorption rate could be shown after subdural and subarachnoid administration of iodine-labelled albumin. The excretion of iohexol was observed for 1 week after the intrathecal injection. For both the subdural and subarachnoid depositions, about 83% of the injected iohexol was found in urine within 24 hr after injection. The total recovery of iohexol after 1 week was 96% (range, 87%-101%).