PT  - JOURNAL ARTICLE
AU  - Kuharik, M A
AU  - Edwards, M K
AU  - Farlow, M R
AU  - Becker, G J
AU  - Azzarelli, B
AU  - Klatte, E C
AU  - Augustyn, G T
AU  - Dreesen, R G
TI  - Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions.
DP  - 1988 Jul 01
TA  - American Journal of Neuroradiology
PG  - 643--648
VI  - 9
IP  - 4
4099  - http://www.ajnr.org/content/9/4/643.short
4100  - http://www.ajnr.org/content/9/4/643.full
SO  - Am. J. Neuroradiol.1988 Jul 01; 9
AB  - Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentiate acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.