RT Journal Article
SR Electronic
T1 Gd-enhanced MR imaging of acute and chronic experimental demyelinating lesions.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 643
OP 648
VO 9
IS 4
A1 Kuharik, M A
A1 Edwards, M K
A1 Farlow, M R
A1 Becker, G J
A1 Azzarelli, B
A1 Klatte, E C
A1 Augustyn, G T
A1 Dreesen, R G
YR 1988
UL http://www.ajnr.org/content/9/4/643.abstract
AB Experimental allergic encephalomyelitis, a demyelinating disease with marked similarity to multiple sclerosis, was produced in two of 12 dogs. All dogs were studied with serial MR imaging. T1- and T2-weighted MR images were obtained both before and after IV Gd-DTPA. Multiple, new periventricular white matter demyelinating lesions were observed after each clinical episode of the disease. Like multiple sclerosis, the acute lesions of experimental allergic encephalomyelitis on T2-weighted MR images were indistinguishable from the older, more chronic lesions. However, after Gd-DTPA, there was bright paramagnetic enhancement of the acute lesions and, in one animal, no enhancement of the chronic lesions on T1-weighted MR images. At necropsy, the differences in the MR paramagnetic enhancement correlated well with the relative histologic age of the demyelinating lesions. Our results suggest that MR with Gd-DTPA may be used to differentiate acute, active demyelinating lesions from the more chronic, inactive lesions in this animal model.