RT Journal Article
SR Electronic
T1 The effect of Gd-dimeglumine on subcutaneous tissues: a study with rats.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 325
OP 327
VO 11
IS 2
A1 McAlister, W H
A1 McAlister, V I
A1 Kissane, J M
YR 1990
UL http://www.ajnr.org/content/11/2/325.abstract
AB Gadopentetate dimeglumine and a saline solution of similar osmolality of 2100 mOs/kg H2O were placed in the paws and in the thigh muscles and subcutaneous tissue of Sprague-Dawley rats weighing 225-250 g. The paws were serially photographed for 4 weeks and the thighs were examined histologically for up to 4 weeks. Gross and histologic reactions to gadopentetate dimeglumine were greater than those to the saline solution, and included tissue sloughs. When risk factors for extravascular extravasation are present, such as infusion sites in the dorsum of the hand or foot, or around the ankle, or when soft tissues are obscured by bandages, caution should be exercised when injecting gadopentetate dimeglumine.