RT Journal Article
SR Electronic
T1 Atypical Diffusion-Restricted Lesion in 5-Fluorouracil Encephalopathy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A2781
A1 Lee, W.-W.
A1 Kim, J.-S.
A1 Son, K.R.
A1 Kwon, H.-M.
YR 2012
UL http://www.ajnr.org/content/early/2012/03/08/ajnr.A2781.abstract
AB SUMMARY: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging. Abbreviations BUNblood urea nitrogenCRFchronic renal failureDPDdihydropyrimidine dehydrogenase5-FU5-fluorouracilPT/INRprothrombin time/international normalized ratio