PT  - JOURNAL ARTICLE
AU  - J A Malko
AU  - J C Hoffman, Jr
AU  - R C Green
TI  - MR measurement of intracranial CSF volume in 41 elderly normal volunteers.
DP  - 1991 Mar 01
TA  - American Journal of Neuroradiology
PG  - 371--374
VI  - 12
IP  - 2
4099  - http://www.ajnr.org/content/12/2/371.short
4100  - http://www.ajnr.org/content/12/2/371.full
SO  - Am. J. Neuroradiol.1991 Mar 01; 12
AB  - A noninvasive nonplanimetric MR protocol was used to measure the total intracranial CSF volume in 41 normal subjects, aged 60-84 years, who were intensively screened to eliminate CNS disease. The protocol entailed application of MR imaging data acquired with a spin-echo sequence in a single thick slice encompassing the head. The results show a strong correlation between increased intracranial CSF volume and increasing age, and a weaker correlation between increased intracranial CSF volume and increasing total intracranial volume. The possibility of employing a CSF volume measurement as a reflection of brain atrophy to help diagnose dementia is discussed.