RT Journal Article
SR Electronic
T1 MR measurement of intracranial CSF volume in 41 elderly normal volunteers.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 371
OP 374
VO 12
IS 2
A1 J A Malko
A1 J C Hoffman, Jr
A1 R C Green
YR 1991
UL http://www.ajnr.org/content/12/2/371.abstract
AB A noninvasive nonplanimetric MR protocol was used to measure the total intracranial CSF volume in 41 normal subjects, aged 60-84 years, who were intensively screened to eliminate CNS disease. The protocol entailed application of MR imaging data acquired with a spin-echo sequence in a single thick slice encompassing the head. The results show a strong correlation between increased intracranial CSF volume and increasing age, and a weaker correlation between increased intracranial CSF volume and increasing total intracranial volume. The possibility of employing a CSF volume measurement as a reflection of brain atrophy to help diagnose dementia is discussed.