PT - JOURNAL ARTICLE AU - Chung, S. AU - Wang, X. AU - Lui, Y.W. TI - Influence of T1-Weighted Signal Intensity on FSL Voxel-Based Morphometry and FreeSurfer Cortical Thickness AID - 10.3174/ajnr.A5053 DP - 2017 Apr 01 TA - American Journal of Neuroradiology PG - 726--728 VI - 38 IP - 4 4099 - http://www.ajnr.org/content/38/4/726.short 4100 - http://www.ajnr.org/content/38/4/726.full SO - Am. J. Neuroradiol.2017 Apr 01; 38 AB - SUMMARY: The effect of T1 signal on FSL voxel-based morphometry modulated GM density and FreeSurfer cortical thickness is explored. The techniques rely on different analyses, but both are commonly used to detect spatial changes in GM. Standard pipelines show FSL voxel-based morphometry is sensitive to T1 signal alterations within a physiologic range, and results can appear discordant between FSL voxel-based morphometry and FreeSurfer cortical thickness. Care should be taken in extrapolating results to the effect on brain volume.CTcortical thicknessmGMmodulated GM densitymTBImild traumatic brain injuryVBMvoxel-based morphometry