RT Journal Article
SR Electronic
T1 Feasibility of Flat Panel Detector CT in Perfusion Assessment of Brain Arteriovenous Malformations: Initial Clinical Experience
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 735
OP 739
DO 10.3174/ajnr.A5091
VO 38
IS 4
A1 M. Garcia
A1 T.W. Okell
A1 M. Gloor
A1 M.A. Chappell
A1 P. Jezzard
A1 O. Bieri
A1 J.V. Byrne
YR 2017
UL http://www.ajnr.org/content/38/4/735.abstract
AB SUMMARY: The different results from flat panel detector CT in various pathologies have provoked some discussion. Our aim was to assess the role of flat panel detector CT in brain arteriovenous malformations, which has not yet been assessed. Five patients with brain arteriovenous malformations were studied with flat panel detector CT, DSC-MR imaging, and vessel-encoded pseudocontinuous arterial spin-labeling. In glomerular brain arteriovenous malformations, perfusion was highest next to the brain arteriovenous malformation with decreasing values with increasing distance from the lesion. An inverse tendency was observed in the proliferative brain arteriovenous malformation. Flat panel detector CT, originally thought to measure blood volume, correlated more closely with arterial spin-labeling-CBF and DSC-CBF than with DSC-CBV. We conclude that flat panel detector CT perfusion depends on the time point chosen for data collection, which is triggered too early in these patients (ie, when contrast agent appears in the superior sagittal sinus after rapid shunting through the brain arteriovenous malformation). This finding, in combination with high data variability, makes flat panel detector CT inappropriate for perfusion assessment in brain arteriovenous malformations.ASLarterial spin-labelingbAVMbrain arteriovenous malformationFPDflat panel detectorpnperinidalrCBFrelative CBFrCBVrelative CBV