RT Journal Article SR Electronic T1 Disappearance of cerebral calcification as a sign of tumor growth. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 119 OP 122 VO 14 IS 1 A1 Halpin, S A1 Kingsley, D YR 1993 UL http://www.ajnr.org/content/14/1/119.abstract AB Calcification occurs in many benign and malignant neurologic disorders. We describe two patients with cerebral glioma, in whom the disappearance of cerebral calcification was evidence of local malignant change. We discuss the underlying chemical mechanisms that result in tissue calcification, and postulate that calcification may disappear in the presence of a malignant tumor because of a decrease in the pH of the microenvironment.