PT  - JOURNAL ARTICLE
AU  - J M Heckmann
AU  - R Eastman
AU  - L Handler
AU  - M Wright
AU  - P Owen
TI  - Leigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.
DP  - 1993 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1157--1159
VI  - 14
IP  - 5
4099  - http://www.ajnr.org/content/14/5/1157.short
4100  - http://www.ajnr.org/content/14/5/1157.full
SO  - Am. J. Neuroradiol.1993 Sep 01; 14
AB  - The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly the mesencephalon, is characteristically involved on MR in the early and late phases of the illness.