RT Journal Article
SR Electronic
T1 Leigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1157
OP 1159
VO 14
IS 5
A1 J M Heckmann
A1 R Eastman
A1 L Handler
A1 M Wright
A1 P Owen
YR 1993
UL http://www.ajnr.org/content/14/5/1157.abstract
AB The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly the mesencephalon, is characteristically involved on MR in the early and late phases of the illness.