PT  - JOURNAL ARTICLE
AU  - Fujii, Y
AU  - Takeuchi, S
AU  - Koike, T
AU  - Nishimaki, K
AU  - Ito, Y
AU  - Tanaka, R
AU  - Okamoto, K
TI  - Heparin administration and monitoring for neuroangiography.
DP  - 1994 Jan 01
TA  - American Journal of Neuroradiology
PG  - 51--54
VI  - 15
IP  - 1
4099  - http://www.ajnr.org/content/15/1/51.short
4100  - http://www.ajnr.org/content/15/1/51.full
SO  - Am. J. Neuroradiol.1994 Jan 01; 15
AB  - PURPOSE To establish the optimal protocol of heparin administration during interventional neuroradiology. METHODS We assessed 100 cases of neuroangiography, including endovascular surgery, and measured activated coagulation time before and 5 minutes after heparin administration, and before and 5 minutes after protamine neutralization. In some cases actual heparin concentration was assayed using a chromogenic substrate technique. RESULTS The actual plasma heparin concentration significantly correlated with the dose of heparin administered intravenously (r = .98; P < .0001) and changes in activated coagulation time (r = .85; P < .0001). The change in activated coagulation time significantly correlated with the dose of heparin injected intravenously (r = .54, P < .0001). The ratio of change in activated coagulation time significantly correlated with time elapsed after heparin administration (r = -.70, P < .0001). CONCLUSIONS The activated coagulation time is useful in monitoring administration and neutralization of heparin during neuroangiography, and a bolus injection of 60 U/kg heparin should be adequate to carry out neuroangiography for 75 minutes safely, even for endovascular surgery.