PT  - JOURNAL ARTICLE
AU  - Kurki, T
AU  - Niemi, P
AU  - Valtonen, S
TI  - MR of intracranial tumors: combined use of gadolinium and magnetization transfer.
DP  - 1994 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1727--1736
VI  - 15
IP  - 9
4099  - http://www.ajnr.org/content/15/9/1727.short
4100  - http://www.ajnr.org/content/15/9/1727.full
SO  - Am. J. Neuroradiol.1994 Oct 01; 15
AB  - PURPOSE To study the potential combined application of gadolinium and magnetization transfer in the MR imaging of intracranial tumors. METHODS Twenty-two patients were imaged at low field strength (0.1 T). Corresponding gradient-echo partial saturation images without and with magnetization transfer pulse were produced. Images with intermediate repetition times were obtained in 18 cases; five different sequences were produced in 4 cases. Gadopentetate dimeglumine was used at a dose of 0.1 mmol/kg. RESULTS Magnetization transfer effect increased the contrast between enhancing lesion and normal brain and the contrast between edema and normal brain; the contrast between enhancing lesion and edema was not significantly changed. On intermediate-repetition-time magnetization transfer images the contrast between enhancing tumor and normal brain and the contrast between edema and normal brain were superior to short-repetition-time magnetization transfer images, but the differentiation between enhancing tumor and edema was poorer. CONCLUSION Magnetization transfer can be used to improve contrast in Gd-enhanced MR imaging. Combining magnetization transfer with an intermediate-repetition-time image provides the possibility for displaying both enhancing and nonenhancing lesions on a single MR image.