RT Journal Article
SR Electronic
T1 Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 29
OP 37
VO 19
IS 1
A1 G J Hunter
A1 L M Hamberg
A1 J A Ponzo
A1 F R Huang-Hellinger
A1 P P Morris
A1 J Rabinov
A1 J Farkas
A1 M H Lev
A1 P W Schaefer
A1 C S Ogilvy
A1 L Schwamm
A1 F S Buonanno
A1 W J Koroshetz
A1 G L Wolf
A1 R G González
YR 1998
UL http://www.ajnr.org/content/19/1/29.abstract
AB PURPOSE Our purpose was to determine the clinical feasibility of quantitative three-dimensional functional CT in patients with hyperacute stroke.METHODS Twenty-two patients who underwent clinically indicated CT angiography were studied: nine patients had no stroke, eight had mature stroke, and five had hyperacute stroke (less than 3 hours since ictus). Maps were obtained of perfused cerebral blood volume (PBV), and CT angiograms were generated by using standard techniques.RESULTS Normal PBV values (mean +/- SEM) were 4.6 +/- 0.15% in the gray matter, 1.75 +/- 0.09% in the white matter, 2.91 +/- 0.20% in the cerebellum, 3.18 +/- 0.10% in the caudate, 2.84 +/- 0.23% in the putamen, 2.92 +/- 0.29% in the thalamus, and 1.66 +/- 0.03% in the brain stem. For patients with mature stroke, ischemic changes were visible on noncontrast, contrast-enhanced, and PBV scans. In patients with hyperacute stroke, ischemic changes were either absent or subtle before contrast administration, but became apparent on contrast-enhanced scans. Quantitative PBV maps confirmed reduced regional perfusion. CT angiograms in the hyperacute group showed occlusion of vessels in locations appropriate to the PBV deficits seen.CONCLUSION Quantitative three-dimensional functional CT is feasible for patients with hyperacute stroke. It is performed by using helical CT techniques, and yields measures of cerebrovascular physiological function, which are useful in this patient population.