PT  - JOURNAL ARTICLE
AU  - Y Ito
AU  - Y Arahata
AU  - Y Goto
AU  - M Hirayama
AU  - M Nagamutsu
AU  - T Yasuda
AU  - T Yanagi
AU  - G Sobue
TI  - Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome.
DP  - 1998 Mar 01
TA  - American Journal of Neuroradiology
PG  - 415--417
VI  - 19
IP  - 3
4099  - http://www.ajnr.org/content/19/3/415.short
4100  - http://www.ajnr.org/content/19/3/415.full
SO  - Am. J. Neuroradiol.1998 Mar 01; 19
AB  - Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.