RT Journal Article
SR Electronic
T1 Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 415
OP 417
VO 19
IS 3
A1 Y Ito
A1 Y Arahata
A1 Y Goto
A1 M Hirayama
A1 M Nagamutsu
A1 T Yasuda
A1 T Yanagi
A1 G Sobue
YR 1998
UL http://www.ajnr.org/content/19/3/415.abstract
AB Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.