PT  - JOURNAL ARTICLE
AU  - Davanzo, P
AU  - Ke, Y
AU  - Thomas, M A
AU  - Anderson, C
AU  - King, B
AU  - Belin, T
AU  - Levitt, J
AU  - Curran, J
AU  - Guze, B
TI  - Proton MR spectroscopy in Lesch-Nyhan disease.
DP  - 1998 Apr 01
TA  - American Journal of Neuroradiology
PG  - 672--674
VI  - 19
IP  - 4
4099  - http://www.ajnr.org/content/19/4/672.short
4100  - http://www.ajnr.org/content/19/4/672.full
SO  - Am. J. Neuroradiol.1998 Apr 01; 19
AB  - In vivo proton spectra for four patients with Lesch-Nyhan disease and four control subjects matched for age and sex were acquired from voxels (1.5 x 1.5 x 1.5 cm3) placed in the prefrontal cortex and striatum. The patients with Lesch-Nyhan disease had decreased metabolites, especially N-acetylaspartate and glutamate/glutamine, only in the prefrontal cortex as compared with the control group. These findings suggest axonal loss in the prefrontal area of this population. The cortical glutamate/glutamine peak decrement does not confirm cytopathologic studies of Lesch-Nyhan disease and deserves further investigation.