RT Journal Article
SR Electronic
T1 Proton MR spectroscopy in Lesch-Nyhan disease.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 672
OP 674
VO 19
IS 4
A1 Davanzo, P
A1 Ke, Y
A1 Thomas, M A
A1 Anderson, C
A1 King, B
A1 Belin, T
A1 Levitt, J
A1 Curran, J
A1 Guze, B
YR 1998
UL http://www.ajnr.org/content/19/4/672.abstract
AB In vivo proton spectra for four patients with Lesch-Nyhan disease and four control subjects matched for age and sex were acquired from voxels (1.5 x 1.5 x 1.5 cm3) placed in the prefrontal cortex and striatum. The patients with Lesch-Nyhan disease had decreased metabolites, especially N-acetylaspartate and glutamate/glutamine, only in the prefrontal cortex as compared with the control group. These findings suggest axonal loss in the prefrontal area of this population. The cortical glutamate/glutamine peak decrement does not confirm cytopathologic studies of Lesch-Nyhan disease and deserves further investigation.