PT  - JOURNAL ARTICLE
AU  - B.P. Kelley
AU  - J.J. Corrigan
AU  - S.C. Patel
AU  - B.D. Griffith
TI  - Neuropsychiatric Lupus with Antibody-Mediated Striatal Encephalitis
AID  - 10.3174/ajnr.A5842
DP  - 2018 Nov 22
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2018/11/22/ajnr.A5842.short
4100  - http://www.ajnr.org/content/early/2018/11/22/ajnr.A5842.full
AB  - SUMMARY: Systemic lupus erythematosus is a chronic autoimmune disease characterized by the production of autoantibodies resulting in tissue injury across multiple organs; up to 50% of patients develop neurologic involvement, collectively referred to as neuropsychiatric systemic lupus erythematosus. The cases in this clinical report will highlight a subtype of neuropsychiatric systemic lupus erythematosus demonstrating imaging findings of striatal inflammation responsive to plasmapheresis similar to those in the subset of N-methyl-D-aspartate receptor autoimmune encephalitis that involves the striatum. Although the cause for this striking imaging appearance is not definitely known, literature will be presented supporting the hypothesis that it is due to peripheral anti-double-stranded DNA antibodies entering the central nervous system to cross-react with N-methyl-D-aspartate receptor antigens.ANAantinuclear antibodydsDNAdouble-stranded DNANMDArN-methyl-D-aspartate receptorNPSLEneuropsychiatric systemic lupus erythematosusSLEsystemic lupus erythematosus