PT  - JOURNAL ARTICLE
AU  - L.C. Wu
AU  - Y. Zhang
AU  - G. Steinberg
AU  - H. Qu
AU  - S. Huang
AU  - M. Cheng
AU  - T. Bliss
AU  - F. Du
AU  - J. Rao
AU  - G. Song
AU  - L. Pisani
AU  - T. Doyle
AU  - S. Conolly
AU  - K. Krishnan
AU  - G. Grant
AU  - M. Wintermark
TI  - A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
AID  - 10.3174/ajnr.A5896
DP  - 2019 Feb 01
TA  - American Journal of Neuroradiology
PG  - 206--212
VI  - 40
IP  - 2
4099  - http://www.ajnr.org/content/40/2/206.short
4100  - http://www.ajnr.org/content/40/2/206.full
SO  - Am. J. Neuroradiol.2019 Feb 01; 40
AB  - SUMMARY: Magnetic particle imaging is an emerging tomographic technique with the potential for simultaneous high-resolution, high-sensitivity, and real-time imaging. Magnetic particle imaging is based on the unique behavior of superparamagnetic iron oxide nanoparticles modeled by the Langevin theory, with the ability to track and quantify nanoparticle concentrations without tissue background noise. It is a promising new imaging technique for multiple applications, including vascular and perfusion imaging, oncology imaging, cell tracking, inflammation imaging, and trauma imaging. In particular, many neuroimaging applications may be enabled and enhanced with magnetic particle imaging. In this review, we will provide an overview of magnetic particle imaging principles and implementation, current applications, promising neuroimaging applications, and practical considerations.FFLfield-free lineFFPfield-free pointFFRfield-free regionMPImagnetic particle imagingSPIOsuperparamagnetic iron oxideSPIONsuperparamagnetic iron oxide nanoparticle