RT Journal Article SR Electronic T1 Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 408 OP 411 DO 10.3174/ajnr.A5962 VO 40 IS 3 A1 Ivanidze, J. A1 Mackay, M. A1 Hoang, A. A1 Chi, J.M. A1 Cheng, K. A1 Aranow, C. A1 Volpe, B. A1 Diamond, B. A1 Sanelli, P.C. YR 2019 UL http://www.ajnr.org/content/40/3/408.abstract AB SUMMARY: We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.BBBPblood-brain barrier permeabilityDCEdynamic contrast-enhancedKtransvolume transfer constantSLEsystemic lupus erythematosusVEvolume in the extravascular extracellular space