PT  - JOURNAL ARTICLE
AU  - C.S. Edeklev
AU  - M. Halvorsen
AU  - G. Løvland
AU  - S.A.S. Vatnehol
AU  - Ø. Gjertsen
AU  - B. Nedregaard
AU  - R. Sletteberg
AU  - G. Ringstad
AU  - P.K. Eide
TI  - Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients
AID  - 10.3174/ajnr.A6136
DP  - 2019 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1257--1264
VI  - 40
IP  - 8
4099  - http://www.ajnr.org/content/40/8/1257.short
4100  - http://www.ajnr.org/content/40/8/1257.full
SO  - Am. J. Neuroradiol.2019 Aug 01; 40
AB  - BACKGROUND AND PURPOSE: Intrathecal contrast-enhanced glymphatic MR imaging has shown promise in assessing glymphatic function in patients with dementia. The purpose of this study was to determine the safety profile and feasibility of this new MR imaging technique.MATERIALS AND METHODS: A prospective safety and feasibility study was performed in 100 consecutive patients (58 women and 42 men, 51 ± 19 years of age) undergoing glymphatic MR imaging from September 2015 to August 2018. Short- and long-term serious and nonserious adverse events were registered clinically and by interview after intrathecal administration of 0.5 mL of gadobutrol (1.0 mmol/mL) along with 3 mL of iodixanol (270 mg I/mL). Adverse events are presented as numbers and percentages.RESULTS: One serious adverse event (anaphylaxis) occurred in a patient with known allergy to iodine-containing contrast agents (1%). The main nonserious adverse events during the first 1–3 days after contrast injection included severe headache (28%) and severe nausea (34%), though the frequency depended heavily on the diagnosis. After 4 weeks, adverse events had resolved.CONCLUSIONS: Intrathecal administration of gadobutrol in conjunction with iodixanol for glymphatic MR imaging is safe and feasible. We cannot conclude whether short-duration symptoms such as headache and nausea were caused by gadobutrol, iodixanol, the lumbar puncture, or the diagnosis. The safety profile closely resembles that of iodixanol alone.gMRIglymphatic MR imagingiNPHidiopathic normal pressure hydrocephalus