PT  - JOURNAL ARTICLE
AU  - G.S. Harrington
AU  - M.H. Buonocore
AU  - S. Tomaszewski Farias
TI  - Intrasubject Reproducibility of Functional MR Imaging Activation in Language Tasks
DP  - 2006 Apr 01
TA  - American Journal of Neuroradiology
PG  - 938--944
VI  - 27
IP  - 4
4099  - http://www.ajnr.org/content/27/4/938.short
4100  - http://www.ajnr.org/content/27/4/938.full
SO  - Am. J. Neuroradiol.2006 Apr 01; 27
AB  - BACKGROUND AND PURPOSE: The purpose of this study was to examine the reproducibility of functional MR imaging (fMRI) activation (volume and laterality) within both inferior frontal and temporoparietal regions of interest for both receptive and expressive language tasks.METHODS: Ten healthy volunteers participated in fMRI experiments for 6 language tasks: verb generation, confrontation naming, semantic decision making, visual sentence comprehension, auditory sentence comprehension, and story listening. Each subject was scanned during 2 separate sessions separated by a minimum of 4 weeks. Laterality of activation was defined by laterality indices (LIs), which were calculated by 2 methods: one method based on the measured volume of activation and the other method based on the F statistic of the activation. Reproducibility was calculated by using concurrence ratios for the volume of activation (Roverlap, Rvolume) and test-retest correlation for LIs.RESULTS: All tasks generated reproducible LIs within at least one of the regions of interest, but verb generation produced the highest test-retest correlations (r = 0.99) within both regions of interest. Verb generation was associated with the highest average concurrence ratios within the inferior frontal region of interest (Roverlap = 45.2; Rvolume = 70.9). In general, the concurrence ratios were lower within the temporoparietal region of interest compared with the inferior frontal region of interest. LIs calculated with F statistics were more reproducible than the LIs calculated by activation volume.CONCLUSION: fMRI is able to provide reproducible LIs in both inferior frontal and temporoparietal regions for assessing hemispheric dominance in language processing. The volume of activation, especially within the temporoparietal regions, is less reproducible than the laterality of activation, so the former should be used with caution.