RT Journal Article
SR Electronic
T1 White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1642
OP 1648
DO 10.3174/ajnr.A6209
VO 40
IS 10
A1 A. Hagiwara
A1 K. Kamagata
A1 K. Shimoji
A1 K. Yokoyama
A1 C. Andica
A1 M. Hori
A1 S. Fujita
A1 T. Maekawa
A1 R. Irie
A1 T. Akashi
A1 A. Wada
A1 M. Suzuki
A1 O. Abe
A1 N. Hattori
A1 S. Aoki
YR 2019
UL http://www.ajnr.org/content/40/10/1642.abstract
AB BACKGROUND AND PURPOSE: A number of MR-derived quantitative metrics have been suggested to assess the pathophysiology of MS, but the reports about combined analyses of these metrics are scarce. Our aim was to assess the spatial distribution of parameters for white matter myelin and axon integrity in patients with relapsing-remitting MS by multiparametric MR imaging.MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting MS and 24 age- and sex-matched controls were prospectively scanned by quantitative synthetic and 2-shell diffusion MR imaging. Synthetic MR imaging data were used to retrieve relaxometry parameters (R1 and R2 relaxation rates and proton density) and myelin volume fraction. Diffusion tensor metrics (fractional anisotropy and mean, axial, and radial diffusivity) and neurite orientation and dispersion index metrics (intracellular volume fraction, isotropic volume fraction, and orientation dispersion index) were retrieved from diffusion MR imaging data. These data were analyzed using Tract-Based Spatial Statistics.RESULTS: Patients with MS showed significantly lower fractional anisotropy and myelin volume fraction and higher isotropic volume fraction in widespread white matter areas. Areas with different isotropic volume fractions were included within areas with lower fractional anisotropy. Myelin volume fraction showed no significant difference in some areas with significantly decreased fractional anisotropy in MS, including in the genu of the corpus callosum and bilateral anterior corona radiata, whereas myelin volume fraction was significantly decreased in some areas where fractional anisotropy showed no significant difference, including the bilateral posterior limb of the internal capsule, external capsule, sagittal striatum, fornix, and uncinate fasciculus.CONCLUSIONS: We found differences in spatial distribution of abnormality in fractional anisotropy, isotropic volume fraction, and myelin volume fraction distribution in MS, which might be useful for characterizing white matter in patients with MS.AVFaxon volume fractionEDSSExpanded Disability Status ScaleFAfractional anisotropyICVFintracellular volume fractionISOisotropic volume fractionMNIMontreal Neurological InstituteMVFmyelin volume fractionNAWMnormal-appearing white matterNODDIneurite orientation dispersion and density imagingODIorientation dispersion indexQRAPMASTERquantification of relaxation times and proton density by multiecho acquisition of a saturation-recovery using turbo spin-echo readout