PT  - JOURNAL ARTICLE
AU  - R. Moftakhar
AU  - B. Aagaard-Kienitz
AU  - K. Johnson
AU  - P.A. Turski
AU  - A.S. Turk
AU  - D.B. Niemann
AU  - D. Consigny
AU  - J. Grinde
AU  - O. Wieben
AU  - C.A. Mistretta
TI  - Noninvasive Measurement of Intra-Aneurysmal Pressure and Flow Pattern Using Phase Contrast with Vastly Undersampled Isotropic Projection Imaging
AID  - 10.3174/ajnr.A0648
DP  - 2007 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1710--1714
VI  - 28
IP  - 9
4099  - http://www.ajnr.org/content/28/9/1710.short
4100  - http://www.ajnr.org/content/28/9/1710.full
SO  - Am. J. Neuroradiol.2007 Oct 01; 28
AB  - BACKGROUND AND PURPOSE: Currently, more reliable parameters to predict the risk of aneurysmal rupture are needed. Intra-aneurysmal pressure gradients and flow maps could provide additional information regarding the risk of rupture. Our hypothesis was that phase contrast with vastly undersampled isotropic projection reconstruction (PC-VIPR), a novel 3D MR imaging sequence, could accurately assess intra-aneurysmal pressure gradients in a canine aneurysmal model when compared with invasive measurements.MATERIALS AND METHODS: A total of 13 surgically created aneurysms in 8 canines were included in this study. Pressure measurements were performed in the parent vessel, aneurysm neck, and 5 regions within the aneurysmal sac with a microcatheter. PC-VIPR sequence was used to obtain cardiac-gated velocity measurements in a region covering the entire aneurysm. The velocity and pressure gradient maps derived from the PC-VIPR data were then coregistered with the anatomic DSA images and compared with catheter measurements.RESULTS: In 7 of the bifurcation aneurysms, the velocity flow maps demonstrated a recirculation flow pattern with a small neck-to-dome pressure gradient (mean, +0.5 mm Hg). In 1 bifurcation aneurysm, a flow jet extending from the neck to the dome with significantly greater pressure gradient (+50.2 mm Hg) was observed. All sidewall aneurysms had low flow in the sac with intermediate pressure gradients (mean, +8.3 mm Hg). High statistical correlation existed between PC-VIPR aneurysmal pressures and microcatheter pressure measurements (R = 0.82, P < .01).CONCLUSION: PC-VIPR can provide anatomic as well as noninvasive quantitative and qualitative hemodynamic information in the canine aneurysm model. The PC-VIPR intra-aneurysmal pressure measurements correlated well with catheter measurements.