PT  - JOURNAL ARTICLE
AU  - D.D. Cavalcanti
AU  - E. Raz
AU  - M. Shapiro
AU  - S. Dehkharghani
AU  - S. Yaghi
AU  - K. Lillemoe
AU  - E. Nossek
AU  - J. Torres
AU  - R. Jain
AU  - H.A. Riina
AU  - A. Radmanesh
AU  - P.K. Nelson
TI  - Cerebral Venous Thrombosis Associated with COVID-19
AID  - 10.3174/ajnr.A6644
DP  - 2020 Jun 18
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2020/06/18/ajnr.A6644.short
4100  - http://www.ajnr.org/content/early/2020/06/18/ajnr.A6644.full
AB  - SUMMARY: Despite the severity of coronavirus disease 2019 (COVID-19) being more frequently related to acute respiratory distress syndrome and acute cardiac and renal injuries, thromboembolic events have been increasingly reported. We report a unique series of young patients with COVID-19 presenting with cerebral venous system thrombosis. Three patients younger than 41 years of age with confirmed Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) infection had neurologic findings related to cerebral venous thrombosis. They were admitted during the short period of 10 days between March and April 2020 and were managed in an academic institution in a large city. One patient had thrombosis in both the superficial and deep systems; another had involvement of the straight sinus, vein of Galen, and internal cerebral veins; and a third patient had thrombosis of the deep medullary veins. Two patients presented with hemorrhagic venous infarcts. The median time from COVID-19 symptoms to a thrombotic event was 7 days (range, 2–7 days). One patient was diagnosed with new-onset diabetic ketoacidosis, and another one used oral contraceptive pills. Two patients were managed with both hydroxychloroquine and azithromycin; one was treated with lopinavir-ritonavir. All patients had a fatal outcome. Severe and potentially fatal deep cerebral thrombosis may complicate the initial clinical presentation of COVID-19. We urge awareness of this atypical manifestation.COVID-19coronavirus disease 2019CVTcerebral venous thrombosisRT-PCRreal-time reverse transcriptase polymerase chain reactionSARS-CoV2Severe Acute Respiratory Syndrome-coronavirus 2