PT - JOURNAL ARTICLE AU - Young, G.S. AU - Setayesh, K. TI - Spin-Echo Echo-Planar Perfusion MR Imaging in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Distinguishing Solitary Metastases from Primary Glioma AID - 10.3174/ajnr.A1239 DP - 2009 Mar 01 TA - American Journal of Neuroradiology PG - 575--577 VI - 30 IP - 3 4099 - http://www.ajnr.org/content/30/3/575.short 4100 - http://www.ajnr.org/content/30/3/575.full SO - Am. J. Neuroradiol.2009 Mar 01; 30 AB - SUMMARY: Unlike the more widely reported gradient-echo echo-planar perfusion-weighted imaging (EPI-PWI) technique, spin-echo (SE) EPI relative cerebral blood volume maps select for blood volume in microvessels <8 μm in diameter. This first report of SE-EPI PWI for distinguishing brain metastasis from high-grade glioma demonstrated 88% sensitivity and 72% specificity in 83 patients. We discuss differences in microvessel architecture between high-grade glioma and brain metastasis that may explain the surprising success of SE-EPI in this application and may deserve further investigation.