PT  - JOURNAL ARTICLE
AU  - Siddiqui, J.
AU  - Bala, F.
AU  - Sciacca, S.
AU  - Falzon, A.M.
AU  - Benger, M.
AU  - Matloob, S.A.
AU  - Miller, F.N.A.C.
AU  - Simister, R.J.
AU  - Chatterjee, I.
AU  - Sztriha, L.K.
AU  - Davagnanam, I.
AU  - Booth, T.C.
TI  - COVID-19 Stroke Apical Lung Examination Study: A Diagnostic and Prognostic Imaging Biomarker in Suspected Acute Stroke
AID  - 10.3174/ajnr.A6832
DP  - 2020 Sep 17
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2020/09/17/ajnr.A6832.short
4100  - http://www.ajnr.org/content/early/2020/09/17/ajnr.A6832.full
AB  - BACKGROUND AND PURPOSE: Diagnosis of coronavirus disease 2019 (COVID-19) relies on clinical features and reverse-transcriptase polymerase chain reaction testing, but the sensitivity is limited. Carotid CTA is a routine acute stroke investigation and includes the lung apices. We evaluated CTA as a potential COVID-19 diagnostic imaging biomarker.MATERIALS AND METHODS: This was a multicenter, retrospective study (n = 225) including CTAs of patients with suspected acute stroke from 3 hyperacute stroke units (March-April 2020). We evaluated the reliability and accuracy of candidate diagnostic imaging biomarkers. Demographics, clinical features, and risk factors for COVID-19 and stroke were analyzed using univariate and multivariate statistics.RESULTS: Apical ground-glass opacification was present in 22.2% (50/225) of patients. Ground-glass opacification had high interrater reliability (Fleiss κ = 0.81; 95% CI, 0.68–0.95) and, compared with reverse-transcriptase polymerase chain reaction, had good diagnostic performance (sensitivity, 75% [95% CI, 56–87]; specificity, 81% [95% CI, 71–88]; OR = 11.65 [95% CI, 4.14–32.78]; P < .001) on multivariate analysis. In contrast, all other contemporaneous demographic, clinical, and imaging features available at CTA were not diagnostic for COVID-19. The presence of apical ground-glass opacification was an independent predictor of increased 30-day mortality (18.0% versus 5.7%, P = .017; hazard ratio = 3.51; 95% CI, 1.42–8.66; P = .006).CONCLUSIONS: We identified a simple, reliable, and accurate COVID-19 diagnostic and prognostic imaging biomarker obtained from CTA lung apices: the presence or absence of ground-glass opacification. Our findings have important implications in the management of patients presenting with suspected stroke through early identification of COVID-19 and the subsequent limitation of disease transmission.BSTIBritish Society of Thoracic ImagingCOVID-19coronavirus disease 2019GGOground-glass opacificationIRRinterrater reliabilityRT-PCRreverse-transcriptase polymerase chain reactionSARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2