RT Journal Article
SR Electronic
T1 Neuropathology for the Neuroradiologist: Plaques and Tangles
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 18
OP 22
DO 10.3174/ajnr.A0781
VO 29
IS 1
A1 Wippold, F.J.
A1 Cairns, N.
A1 Vo, K.
A1 Holtzman, D.M.
A1 Morris, J.C.
YR 2008
UL http://www.ajnr.org/content/29/1/18.abstract
AB SUMMARY: Histologically identified intracellular and extracellular inclusions and structures often provide a tissue diagnosis of a specific disease process. Moreover, these deposits may provide clues about the pathogenesis of the disease in which they are found. Two distinctive structures seen within the brains of patients clinically diagnosed with dementia of the Alzheimer type are extracellular plaques and intracellular neurofibrillary tangles. The purpose of this report is to review the significance of plaques and neurofibrillary tangles in the context of Alzheimer disease.