PT  - JOURNAL ARTICLE
AU  - A.J. Bastos-Leite
AU  - J.P.A. Kuijer
AU  - S.A.R.B. Rombouts
AU  - E. Sanz-Arigita
AU  - E.C. van Straaten
AU  - A.A. Gouw
AU  - W.M. van der Flier
AU  - P. Scheltens
AU  - F. Barkhof
TI  - Cerebral Blood Flow by Using Pulsed Arterial Spin-Labeling in Elderly Subjects with White Matter Hyperintensities
AID  - 10.3174/ajnr.A1091
DP  - 2008 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1296--1301
VI  - 29
IP  - 7
4099  - http://www.ajnr.org/content/29/7/1296.short
4100  - http://www.ajnr.org/content/29/7/1296.full
SO  - Am. J. Neuroradiol.2008 Aug 01; 29
AB  - BACKGROUND AND PURPOSE: On MR imaging, white matter hyperintensities (WMH) on T2-weighted images are generally considered as a surrogate marker of ischemic small vessel disease in elderly subjects. Pulsed arterial spin-labeling (PASL) is a noninvasive MR perfusion-weighted technique. We hypothesized that elderly subjects with diffuse confluent WMH should have lower cerebral blood flow (CBF) measurements than subjects with punctiform or beginning confluent WMH.MATERIALS AND METHODS: MR images of 21 subjects (13 women; mean age, 76 years; SD, 5), stratified for the degree of WMH, from a single center within the multinational Leukoaraiosis and Disability (LADIS) study, were investigated. CBF images were obtained by means of quantitative imaging of perfusion by using a single-subtraction second version, with thin-section TI periodic saturation PASL. Values of cortical gray matter, subcortical (including white matter and deep gray matter), and global CBF were calculated. CBF measurements of subjects with diffuse confluent WMH (n = 7) were compared with those of subjects with punctiform or beginning confluent WMH (n = 14).RESULTS: Subjects with diffuse confluent WMH were found to have approximately 20% lower mean global CBF (43.5 mL/100 mL/min; SD, 6.3) than subjects with punctiform or beginning confluent WMH (57.9 mL/100 mL/min; SD, 8.6; P &amp;lt; .01), as well as approximately 20% lower mean subcortical (P &amp;lt; .01) and cortical gray matter CBF (P &amp;lt; .05).CONCLUSION: PASL revealed a significant reduction of CBF measurements in elderly subjects with diffuse confluent WMH.