RT Journal Article
SR Electronic
T1 Imaging Review of Paraneoplastic Neurologic Syndromes
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2176
OP 2187
DO 10.3174/ajnr.A6815
VO 41
IS 12
A1 Madhavan, A.A.
A1 Carr, C.M.
A1 Morris, P.P.
A1 Flanagan, E.P.
A1 Kotsenas, A.L.
A1 Hunt, C.H.
A1 Eckel, L.J.
A1 Lindell, E.P.
A1 Diehn, F.E.
YR 2020
UL http://www.ajnr.org/content/41/12/2176.abstract
AB SUMMARY: Paraneoplastic syndromes are systemic reactions to neoplasms mediated by immunologic or hormonal mechanisms. The most well-recognized paraneoplastic neurologic syndrome, both clinically and on imaging, is limbic encephalitis. However, numerous additional clinically described syndromes affect the brain, spinal cord, and peripheral nerves. Many of these syndromes can have imaging findings that, though less well described, are important in making the correct diagnosis. Moreover, imaging in these syndromes frequently mimics more common pathology, which can be a diagnostic challenge for radiologists. Our goal is to review the imaging findings of paraneoplastic neurologic syndromes, including less well-known entities and atypical presentations of common entities. Specifically, we discuss limbic encephalitis, paraneoplastic cerebellar degeneration, paraneoplastic brain stem encephalitis, cranial neuropathy, myelitis, and polyneuropathy. We also demonstrate common diagnostic pitfalls that can be encountered when imaging these patients.ANNAantineuronal nuclear autoantibodyPNSparaneoplastic neurologic syndromePCDparaneoplastic cerebellar degeneration