RT Journal Article
SR Electronic
T1 Diagnostic Accuracy of Arterial Spin-Labeling MR Imaging in Detecting the Epileptogenic Zone: Systematic Review and Meta-analysis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1052
OP 1060
DO 10.3174/ajnr.A7061
VO 42
IS 6
A1 J.Y. Zeng
A1 X.Q. Hu
A1 J.F. Xu
A1 W.J. Zhu
A1 H.Y. Wu
A1 F.J. Dong
YR 2021
UL http://www.ajnr.org/content/42/6/1052.abstract
AB BACKGROUND: A noninvasive, safe, and economic imaging technique is required to identify epileptogenic lesions in the brain.PURPOSE: Our aim was to perform a meta-analysis evaluating the accuracy of arterial spin-labeling in localizing the epileptic focus in the brain and the changes in the blood perfusion in these regions.DATA SOURCES: Our sources were the PubMed and EMBASE data bases.STUDY SELECTION: English language studies that assessed the diagnostic accuracy of arterial spin-labeling for detecting the epileptogenic zone up to July 2019 were included.DATA ANALYSIS: The symptomatogenic foci of seizures in the brain were determined and used as the references. The relevant studies were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. The outcomes were evaluated using the pooled sensitivity, pooled specificity, pooled accuracy, diagnostic odds ratio, area under the summary receiver operating characteristic curve, and likelihood ratio.DATA SYNTHESIS: Six studies that included 174 patients qualified for this meta-analysis. The pooled sensitivity, pooled specificity, and area under the summary receiver operating characteristic curve were 0.74 (95% CI, 0.65–0.82), 0.35 (95% CI, 0.03–0.90), and 0.73 (95% CI, 0.69–0.76), respectively. The accuracy of arterial spin-labeling for localizing the epileptic focus was 0.88 (accuracy in arterial spin-labeling/all perfusion changes in arterial spin-labeling) in cases of a positive arterial spin-labeling result. The epileptogenic zone exhibited hyperperfusion or hypoperfusion.LIMITATIONS: Only a few studies were enrolled due to the strict inclusion criteria.CONCLUSIONS: Arterial spin-labeling can be used for assessing, monitoring, and reviewing, postoperatively, patients with epilepsy. Blood perfusion changes in the brain may be closely related to the seizure time and pattern.ASLarterial spin-labelingQUADAS-2Quality Assessment of Diagnostic Accuracy Studies-2SOZseizure onset zone