RT Journal Article
SR Electronic
T1 Embolization with cellulose porous beads, II: Clinical trial.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1901
OP 1906
VO 17
IS 10
A1 J Hamada
A1 Y Kai
A1 S Nagahiro
A1 N Hashimoto
A1 H Iwata
A1 Y Ushio
YR 1996
UL http://www.ajnr.org/content/17/10/1901.abstract
AB PURPOSE To evaluate the clinical applicability of cellulose porous beads (CPBs) as an embolic material for permanent vascular occlusion.METHODS Embolization with CPBs was performed in 16 patients, six with meningioma of the sphenoid wing, two with meningioma of the falx, three with meningioma of the tentorium, two with dural arteriovenous fistula, one with paraganglioma, and two with spinal arteriovenous malformation. Surgical specimens were examined histologically.RESULTS No complications were encountered in any of the 16 patients. Angiograms obtained after embolization showed satisfactory vascular stasis in all cases. Histologic examination of surgical specimens disclosed that vessels having approximately the same caliber as the CPB particles were occluded without stretching of the vessel wall. Larger vessels were occluded by aggregates of many particles, which left no open spaces. Although a few inflammatory cells were seen in the thrombosed vessels, inflammation evoked by CPB was mild and did not extend to either the vessel wall or to surrounding tissues.CONCLUSION CPBs were easy to inject through microcatheters, traveled to distal sites, and produced homogeneous and peripheral embolization without inflammatory changes different from other embolic materials. CPBs are a good embolic material for permanent occlusion in the clinical setting.