@article {Hom41, author = {J. Hom and J.W. Dankbaar and B.P. Soares and T. Schneider and S.-C. Cheng and J. Bredno and B.C. Lau and W. Smith and W.P. Dillon and M. Wintermark}, title = {Blood-Brain Barrier Permeability Assessed by Perfusion CT Predicts Symptomatic Hemorrhagic Transformation and Malignant Edema in Acute Ischemic Stroke}, volume = {32}, number = {1}, pages = {41--48}, year = {2011}, doi = {10.3174/ajnr.A2244}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: SHT and ME are feared complications in patients with acute ischemic stroke. They occur \>10 times more frequently in tPA-treated versus placebo-treated patients. Our goal was to evaluate the sensitivity and specificity of admission BBBP measurements derived from PCT in predicting the development of SHT and ME in patients with acute ischemic stroke. MATERIALS AND METHODS: We retrospectively analyzed a dataset consisting of 32 consecutive patients with acute ischemic stroke with appropriate admission and follow-up imaging. We calculated admission BBBP by using delayed-acquisition PCT data and the Patlak model. Collateral flow was assessed on the admission CTA, while recanalization and reperfusion were assessed on the follow-up CTA and PCT, respectively. SHT and ME were defined according to ECASS III criteria. Clinical data were obtained from chart review. In our univariate and forward selection-based multivariate analysis for predictors of SHT and ME, we incorporated both clinical and imaging variables, including age, admission NIHSS score, admission blood glucose level, admission blood pressure, time from symptom onset to scanning, treatment type, admission PCT{\textendash}defined infarct volume, admission BBBP, collateral flow, recanalization, and reperfusion. Optimal sensitivity and specificity for SHT and ME prediction were calculated by using ROC analysis. RESULTS: In our sample of 32 patients, 3 developed SHT and 3 developed ME. Of the 3 patients with SHT, 2 received IV tPA, while 1 received IA tPA and treatment with the Merci device; of the 3 patients with ME, 2 received IV tPA, while 1 received IA tPA and treatment with the Merci device. Admission BBBP measurements above the threshold were 100\% sensitive and 79\% specific in predicting SHT and ME. Furthermore, all patients with SHT and ME{\textemdash}and only those with SHT and ME{\textemdash}had admission BBBP measurements above the threshold, were older than 65 years of age, and received tPA. Admission BBBP, age, and tPA were the independent predictors of SHT and ME in our forward selection-based multivariate analysis. Of these 3 variables, only BBBP measurements and age were known before making the decision of administering tPA and thus are clinically meaningful. CONCLUSIONS: Admission BBBP, a pretreatment measurement, was 100\% sensitive and 79\% specific in predicting SHT and ME. ACAanterior cerebral arteryBBBPblood-brain barrier permeabilityCBVcerebral blood volumeCTACT angiographyECASSEuropean Cooperative Acute Stroke StudyHThemorrhagic transformationICAinternal carotid arteryIAintra-arterialINRinternational normalized ratioIVintravenousMCAmiddle cerebral arteryMEmalignant edemaMMP-9matrix metalloproteinase-9MTTmean transit timeNCCTnoncontrast CTNIHSSNational Institutes of Health Stroke ScaleORodds ratioPCAposterior cerebral arteryPCTperfusion CTPH-2parenchymal hematoma type 2ROCreceiver operating characteristic analysisSHTsymptomatic hemorrhagic transformationtPAtissue plasminogen activator}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/32/1/41}, eprint = {https://www.ajnr.org/content/32/1/41.full.pdf}, journal = {American Journal of Neuroradiology} }