PT  - JOURNAL ARTICLE
AU  - Uggetti, C
AU  - Egitto, M G
AU  - Fazzi, E
AU  - Bianchi, P E
AU  - Bergamaschi, R
AU  - Zappoli, F
AU  - Sibilla, L
AU  - Martelli, A
AU  - Lanzi, G
TI  - Cerebral visual impairment in periventricular leukomalacia: MR correlation.
DP  - 1996 May 01
TA  - American Journal of Neuroradiology
PG  - 979--985
VI  - 17
IP  - 5
4099  - http://www.ajnr.org/content/17/5/979.short
4100  - http://www.ajnr.org/content/17/5/979.full
SO  - Am. J. Neuroradiol.1996 May 01; 17
AB  - PURPOSE To evaluate the involvement of central visual pathways in cases of periventricular leukomalacia, and to correlate the neuroradiologic findings with the degree of visual acuity.METHODS The MR brain examinations of 27 preterm children affected by cerebral palsy resulting from periventricular leukomalacia and without significant ophthalmologic lesions were reviewed retrospectively to search for possible involvement of the optic radiations and/or of the calcarine cortex. The data were compared with the degree of visual acuity estimated by means of the Teller Acuity Cards test.RESULTS Seventeen (63%) of the 27 patients had cerebral visual impairment, which correlated strongly with MR lesions. Quantitative reduction and signal hyperintensity of the peritrigonal white matter and atrophy of the calcarine cortex were present in the more severe cases. In two blind patients, an altered MR signal was detected in the lateral geniculate bodies.CONCLUSION This study clearly establishes a relationship between specific MR findings and visual impairment in children with periventricular leukomalacia. The finding of hyperintensity in the lateral geniculate bodies was interpreted as an axonal reaction. MR imaging is useful for detecting potential visual impairment and for improving clinical diagnosis.