RT Journal Article
SR Electronic
T1 Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1041
OP 1049
VO 17
IS 6
A1 Petrella, J R
A1 Grossman, R I
A1 McGowan, J C
A1 Campbell, G
A1 Cohen, J A
YR 1996
UL http://www.ajnr.org/content/17/6/1041.abstract
AB PURPOSE To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect.METHODS Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.RESULTS The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.CONCLUSION We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.