RT Journal Article SR Electronic T1 Complex Bilobular, Bisaccular, and Broad-Neck Microsurgical Aneurysm Formation in the Rabbit Bifurcation Model for the Study of Upcoming Endovascular Techniques JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 772 OP 777 DO 10.3174/ajnr.A2374 VO 32 IS 4 A1 S. Marbacher A1 S. Erhardt A1 J.-A. Schläppi A1 D. Coluccia A1 L. Remonda A1 J. Fandino A1 C. Sherif YR 2011 UL http://www.ajnr.org/content/32/4/772.abstract AB BACKGROUND AND PURPOSE: Despite rapid advances in the development of materials and techniques for endovascular intracranial aneurysm treatment, occlusion of large broad-neck aneurysms remains a challenge. Animal models featuring complex aneurysm architecture are needed to test endovascular innovations and train interventionalists. MATERIALS AND METHODS: Eleven adult female New Zealand rabbits were assigned to 3 experimental groups. Complex bilobular, bisaccular, and broad-neck venous pouch aneurysms were surgically formed at an artificially created bifurcation of both CCAs. Three and 5 weeks postoperatively, the rabbits underwent 2D-DSA and CE-3D-MRA, respectively. RESULTS: Mortality was 0%. We observed no neurologic, respiratory, or gastrointestinal complications. The aneurysm patency rate was 91% (1 aneurysm thrombosis). There was 1 postoperative aneurysm hemorrhage (9% morbidity). The mean aneurysm volumes were 176.9 ± 63.6 mm3, 298.6 ± 75.2 mm3, and 183.4 ± 72.4 mm3 in bilobular, bisaccular, and broad-neck aneurysms, respectively. The mean operation time was 245 minutes (range, 175–290 minutes). An average of 27 ± 4 interrupted sutures (range, 21–32) were needed to create the aneurysms. CONCLUSIONS: This study demonstrates the feasibility of creating complex venous pouch bifurcation aneurysms in the rabbit with low morbidity, mortality, and high short-term aneurysm patency. The necks, domes, and volumes of the bilobular, bisaccular, and broad-neck aneurysms created are larger than those previously described. These new complex aneurysm formations are a promising tool for in vivo animal testing of new endovascular devices. BLbilobularBNbroad-neckBSbisaccularCCAcommon carotid arteryCE-3D-MRAcontrast-enhanced 3D MRADSAdigital subtraction angiography2D-DSA2D intra-arterial DSALCCAleft CCA (p-LCCA = proximal LCCA, d-LCCA = distal LCCA)MRAMR angiographyRCCAright CCATOFtime-of-flightVPvenous pouch