RT Journal Article
SR Electronic
T1 MR Imaging Findings in Patients with Secondary Intracranial Hypertension
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1021
OP 1029
DO 10.3174/ajnr.A2463
VO 32
IS 6
A1 A.C. Rohr
A1 C. Riedel
A1 M.-C. Fruehauf
A1 A. van Baalen
A1 T. Bartsch
A1 J. Hedderich
A1 K. Alfke
A1 L. Doerner
A1 O. Jansen
YR 2011
UL http://www.ajnr.org/content/32/6/1021.abstract
AB BACKGROUND AND PURPOSE: IH can alter the configuration of anatomic structures of the central nervous system. We determined the sensitivity and specificity of MR imaging to detect these changes in patients with secondary IH. MATERIALS AND METHODS: Patients (n = 36) with IH were prospectively investigated with MR imaging and were matched to 36 controls. MR images were evaluated for elongation and edema of the optic nerves, protrusion of the optic disc, flattening of the posterior sclera, height of the pituitary gland, and width of the optic nerve sheath. On MRV, we recorded venous sinus abnormalities and measured the luminal width of the superior ophthalmic veins. A grading score was introduced to define cranial venous outflow obstruction. RESULTS: Cranial venous outflow obstruction and ONS hydrops were the most valid signs indicating IH with a sensitivity of 94% and 92% and a specificity of 100% and 89%, respectively. Sensitivities and specificities were 56% and 97% for reduced pituitary height, 64% and 78% for flattening of the posterior sclera, 31% and 97% for widening of the superior ophthalmic veins, 33% and 100% for optic disc protrusion, 14% and 100% for optic nerve edema, and 6% and 100% for elongation of the optic nerve. At least 2 MR imaging findings could be demonstrated in each patient but in none of the controls. The number of positive MR imaging findings correlated with CSF pressure (r = 0.62, P = .01). CONCLUSIONS: The combination of cranial and orbital MR imaging and MRV can be highly sensitive and specific in the diagnosis of patients with IH. CIconfidence intervalCVOOcranial venous outflow obstructionFLAIRfluid-attenuated inversion recoveryICCintraclass correlation coefficientIHintracranial hypertensionIIHidiopathic intracranial hypertensionIJVinternal jugular veinLPlumbar punctureLTSleft transverse sinusMIPmaximum intensity projectionMRIMR imagingMRVMR venographyONSoptic nerve sheathORodds ratioPRESposterior reversible encephalopathy syndromeRTSright transverse sinusSIHsecondary intracranial hypertensionSOVsuperior ophthalmic veinSSSsuperior sagittal sinusSTIRshort tau inversion recoveryT1WIT1-weighted imagingT2WIT2-weighted imagingTStransverse/sigmoid sinusTSEturbo spin-echoVIvisual impairment