RT Journal Article
SR Electronic
T1 Pulsatility Index in the Basal Ganglia Arteries Increases with Age in Elderly with and without Cerebral Small Vessel Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 540
OP 546
DO 10.3174/ajnr.A7450
VO 43
IS 4
A1 V. Perosa
A1 T. Arts
A1 A. Assmann
A1 H. Mattern
A1 O. Speck
A1 J. Oltmer
A1 H.-J. Heinze
A1 E. Düzel
A1 S. Schreiber
A1 J.J.M. Zwanenburg
YR 2022
UL http://www.ajnr.org/content/43/4/540.abstract
AB BACKGROUND AND PURPOSE: Cerebral small vessel disease contributes to stroke and cognitive impairment and interacts with Alzheimer disease pathology. Because of the small dimensions of the affected vessels, in vivo characterization of blood flow properties is challenging but important to unravel the underlying mechanisms of the disease.MATERIALS AND METHODS: A 2D phase-contrast sequence at 7T MR imaging was used to assess blood flow velocity and the pulsatility index of the perforating basal ganglia arteries. We included patients with cerebral amyloid angiopathy (n = 8; identified through the modified Boston criteria), hypertensive arteriopathy (n = 12; identified through the presence of strictly deep or mixed cerebral microbleeds), and age- and sex-matched controls (n = 28; no cerebral microbleeds).RESULTS: Older age was related to a greater pulsatility index, irrespective of cerebral small vessel disease. In hypertensive arteriopathy, there was an association between lower blood flow velocity of the basal ganglia and the presence of peri-basal ganglia WM hyperintensities.CONCLUSIONS: Our results suggest that age might be the driving factor for altered cerebral small vessel hemodynamics. Furthermore, this study puts cerebral small vessel disease downstream pathologies in the basal ganglia region in relation to blood flow characteristics of the basal ganglia microvasculature.BGbasal gangliaCAAcerebral amyloid angiopathycSScortical superficial siderosisCSVDcerebral small vessel diseaseEPVSenlarged perivascular spacesHAhypertensive arteriopathyICHintracerebral hemorrhageMBsmicrobleedsPCphase-contrastPIpulsatility indexVmeanmean blood flow velocityWMHWM hyperintensities