PT  - JOURNAL ARTICLE
AU  - Wang, X.-C.
AU  - Gao, P.-Y.
AU  - Xue, J.
AU  - Liu, G.-R.
AU  - Ma, L.
TI  - Identification of Infarct Core and Penumbra in Acute Stroke Using CT Perfusion Source Images
AID  - 10.3174/ajnr.A1740
DP  - 2010 Jan 01
TA  - American Journal of Neuroradiology
PG  - 34--39
VI  - 31
IP  - 1
4099  - http://www.ajnr.org/content/31/1/34.short
4100  - http://www.ajnr.org/content/31/1/34.full
SO  - Am. J. Neuroradiol.2010 Jan 01; 31
AB  - BACKGROUND AND PURPOSE: CT perfusion (CTP) mapping has been reported to be useful in the differentiation of the infarct core and ischemic penumbra. However, the value of the CTP source imaging (CTP-SI) during the arterial and venous phases has not been fully investigated. The purpose of this study was to develop a CTP-SI methodology for acute ischemic stroke and compare its efficacy with cerebral blood flow (CBF) and cerebral blood volume (CBV) in predicting infarct core and penumbra. MATERIALS AND METHODS: CT examinations, including non-contrast-enhanced CT, CTP, and CT angiography (CTA), were performed in 42 patients with symptoms of stroke for <9 hours. The Alberta Stroke Program Early CT Score (ASPECTS) was analyzed on the arterial phase CTP-SI and venous phase CTP-SI and then compared with the ASPECTS on CBF and CBV for efficacy assessment. RESULTS: The ASPECTS on the arterial phase CTP-SI was closely correlated with the ASPECTS on CBF, the Pearson correlation coefficient was 0.88 (P < .001), and the concordance correlation coefficient was 0.7603 (95% confidence interval [CI], 0.6331–0.8476). The ASPECTS on the venous phase CTP-SI revealed a significant correlation with the ASPECTS on CBV, the Pearson correlation coefficient was 0.92 (P < .001), and the concordance correlation coefficient was 0.8880 (95% CI, 0.8148–0.9334). Significant differences were shown between the arterial phase CTP-SI/ venous phase CTP-SI (P < .001) and CBF/CBV (P < .001). CONCLUSIONS: This study provides preliminary evidence that the arterial phase and venous phase CTP-SI mismatch model could possibly be applied to ischemic regions in the acute stage of stroke to determine penumbra and infarct core.