RT Journal Article
SR Electronic
T1 The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1769
OP 1777
DO 10.3174/ajnr.A2043
VO 31
IS 10
A1 F. Agosta
A1 A. Chiò
A1 M. Cosottini
A1 N. De Stefano
A1 A. Falini
A1 M. Mascalchi
A1 M.A. Rocca
A1 V. Silani
A1 G. Tedeschi
A1 M. Filippi
YR 2010
UL http://www.ajnr.org/content/31/10/1769.abstract
AB SUMMARY: In patients with ALS, conventional MR imaging is frequently noninformative, and its use has been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive application of modern MR imaging−based techniques to the study of ALS has undoubtedly improved our understanding of disease pathophysiology and is likely to have a role in the identification of potential biomarkers of disease progression. This review summarizes how new MR imaging technology is changing dramatically our understanding of the factors associated with ALS evolution and highlights the reasons why it should be used more extensively in studies of disease progression, including clinical trials. ALSamyotrophic lateral sclerosisALSFRSALS Functional Rating ScaleChocholineCrcreatineCSTcorticospinal tractDTIdiffusion tensor imagingFAfractional anisotropyFLAIRfluid-attenuated inversion recoveryfMRIfunctional MR imagingFTDfrontotemporal dementiaFUS/TLSfused in sarcoma/translocated in liposarcoma geneGMgray matter1H-MR spectroscopyproton MR spectroscopyLleftLMNlower motor neuronMDmean diffusivitymInsmyo-inositolMTmagnetization transferMTRMT ratioNAAN-acetylaspartatensnot significantPDproton densityRrightSOD1superoxide dismutase 1SPMstatistical parametric mappingTDP-43TAR DNA-binding protein geneUMNupper motor neuronVBMvoxel-based morphometryWMwhite matter